Obesity Epidemiology
In obese diabetic KK-Ay mice gene expression in the liver varies with time
Published in Obesity and Diabetes Week, September 11th, 2006
According to a study from Japan, "Although a number of genes expressed in most tissues, including the liver, exhibit circadian regulation, gene expression profiles are usually examined only at one scheduled time each day. In this study, we investigated the effects of obese diabetes on the hepatic mRNA levels of various genes at 6-h intervals over a single 24-h period."
"Microarray analysis revealed that many genes are expressed rhythmically, not only in control KK mice but also in obese diabetic KK-Ay mice. Real-time quantitative PCR verified that 19 of...
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