Diabetes Complications
Insulin therapy linked to platelet dysfunction in diabetics on dual oral antiplatelet therapy
Published in Obesity and Diabetes Week, September 18th, 2006
According to a study from the United States, "This study sought to assess the influence of type 2 diabetes mellitus (T2DM) and the impact of hypoglycemic treatment (insulin vs. noninsulin) on platelet function profiles in patients treated with dual oral antiplatelet therapy."
"Insulin inhibits platelet aggregation by suppressing the P2Y12 pathway. However, T2DM patients have a loss of responsiveness to insulin that leads to upregulation of the P2Y12 pathway, increased platelet reactivity, and...
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