Published in Obesity and Diabetes Week, September 18th, 2006
According to recent research from England, "Heterozygous activating mutations in KCNJ11, encoding the Kir6.2 subunit of the ATP-sensitive potassium (KATP ) channel, cause 30 to 58% of cases of diabetes diagnosed in patients under 6 months of age. Patients present with ketoacidosis or severe hyperglycemia and are treated with insulin. Diabetes results from impaired insulin secretion caused by a failure of the beta-cell KATP channel to close in response to increased intracellular ATP. Sulfonylureas close the KATP channel by an...
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