Atherosclerosis
Atherosclerotic model is developed using transgenic mice expressing MPO-463G/A alleles
Published in Obesity and Diabetes Week, September 18th, 2006
"Myeloperoxidase (MPO) is an oxidant-generating enzyme present in macrophages at atherosclerotic lesions and implicated in coronary artery disease (CAD). Although mouse models are important for investigating the role of MPO in atherosclerosis, neither mouse MPO nor its oxidation products are detected in lesions in murine models," scientists writing in the Journal of Lipid Research report.
"To circumvent this problem," proposed L.W. Castellani and colleagues, Sidney Kimmel Cancer Center, "we generated transgenic mice expressing two...
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