Obesity Complications
CLOCK is involved in obesity-induced disordered fibrinolysis by regulating PAI-1 expression
Published in Obesity and Diabetes Week, September 25th, 2006
According to recent research published in the Journal of Thrombosis and Haemostasis, "An increased level of obesity-induced plasma plasminogen activator inhibitor-1 (PAI-1) is considered a risk factor for cardiovascular disease. The present study investigates whether the circadian clock component CLOCK is involved in obesity-induced PAI-1 elevation. We examined plasma PAI-1 and mRNA expression levels in tissues from leptin-deficient obese and diabetic ob/ob mice lacking functional CLOCK protein."
"Our results demonstrated," reported...
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