Obesity Therapy
Obesity drug designed to produce a 5-HT2C receptor agonist
Published in Obesity and Diabetes Week, September 25th, 2006
"5-HT2C agonists have shown efficacy in limiting food consumption and thus may serve as an important drug class in combating obesity," scientists in the United States report.
"We describe the design and synthesis of a novel tricyclic single-nitrogen scaffold that was used to produce 5-HT2C agonists. SAR was developed around this chemotype and compounds were identified that were potent (Ki <15 nM) and selective relative to other 5-HT2 receptors," wrote B.R. Huck and colleagues,...
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