Obesity and Diabetes Week

Diabetes & Obesity - Atherosclerosis related gene identified in LDL receptor-deficient C57BL/6 mice

Diabetes & Obesity - Ghrelin does not significantly alter glucose or insulin levels in obese women

Diabetes Therapy - Thiazolidinedione reverses low fatty acid oxidation and high lipogenesis in obese diabetics

Insulin Resistance - Long-term interleukin-1 beta treatment induces insulin resistance in human adipocytes

Obesity & Cardiovascular Disease - ^99mTc-tetrofosmin myocardial perfusion imaging can predict cardiac mortality in obese

Adiposity - Adiposity and left ventricular mass are related in childhood and into young adulthood

Angiology - Childhood C-reactive protein values predict adult values independent

Apoptosis - Pancreatic beta-cell apoptosis involves transcription factor activation

Apoptosis - Pancreatic beta-cell mediated death requires proapoptotic molecule

Bariatric Surgery - Glucose tolerance was restored due to large insulin sensitivity improvements after BPD

Body Mass Index - Bupropion plus low-key dietary intervention reduce olanzapine-associated weight gain

Business & Finance - Hi-Tech Pharmacal reports Q1 results; net sales were $11,318,000

Business Update - Allergan launches new gastric band to treat morbid obesity

Cancer Research - Regular exercise significantly reduces markers of increased colon-cancer risk in men

Cardiology - Data on Lipitor use in heart disease, metabolic syndrome published

Cardiovascular Disease - C-reactive protein linked to cardiovascular disease in people with diabetes

Cardiovascular Disease - In type 2 diabetes, chronic kidney disease was associated with increased artery stiffness

Cardiovascular Disease - Microalbuminuria and risk for cardiovascular disease are reviewed

Cardiovascular Research - Researchers find statins reduce inflammation in patients with metabolic syndrome

Collaborations - Ajinomoto, Sankyo reach agreement to develop, market new diabetes drug AJD101

Diabetes & Obesity - JTP-426467 acts as selective peroxisome proliferator-activated receptor gamma antagonist

Diabetes & Obesity - Reduced cardiac efficiency in obesity and diabetes is reviewed

Diabetes & Tuberculosis - Type 1 diabetes occurrence inversely correlates with tuberculosis incidence

Diabetes Complications - Blood flow velocity reduction may raise retinal thickness of macula in diabetic macular edema

Diabetes Complications - Delayed diabetic foot ulcer healing is seen with low foot skin innervation and neurogenic factors

Diabetes Complications - Dexamethasone treatments similar in effectiveness for hearing loss with diabetes

Diabetes Complications - Diabetes may alter renal blood flow versus nonrenal blood flow control

Diabetes Complications - In type 1 diabetes, impaired esophageal motility is more frequent in conjunction with CVAN

Diabetes Control - Glycemic control obtained without weight gain in type 2 diabetics using GAME regimen

Diabetes Control - In newly diagnosed type 2 diabetics, weight loss was common and not affected by sulfonylurea

Diabetes Control - Insulin responses are inhibited by resveratrol

Diabetes Control - Once-daily oral diabetes treatment Glumetza available

Diabetes Control - Type 1 diabetes glucose control with insulin reduces blood cell binding activity

Diabetes Epidemiology - Diabetes does not appear to be linked to PPP1R3B gene in Caucasians but may be in Japanese

Diabetes Epidemiology - Diabetics of low socioeconomic status had greater adherence to preventive healthcare

Diabetes Epidemiology - Genes involved in pancreatic beta-cell function in type 2 diabetes in Japanese are examined

Diabetes Epidemiology - Transient neonatal diabetes mellitus region variants do not impact type 2 diabetes risk

Diabetes Epidemiology - Type 1 diabetes rate is higher in remote areas in the U.K.

Diabetes Epidemiology - Type 2 diabetes was not associated with ENPP1 codon 121 Q allele in Danish subjects

Diabetes Pathogenesis - Beta cell compensation for insulin resistance is related to lipolysis and fatty acid signaling

Diabetes Pathogenesis - Dysregulation of muscle fatty acid metabolism in type 2 diabetes is independent of malonyl-CoA

Diabetes Pathogenesis - Early alterations in myocardia and vessels of diabetic rat hearts are investigated

Diabetes Pathogenesis - Electrogastrography derangement is present in 71% of newly diagnosed type 1 diabetes

Diabetes Pathogenesis - Free fatty acids inhibit vascular insulin signaling and eNOS activation

Diabetes Pathogenesis - Glomerular injury is exacerbated in diabetic integrin alpha 1-null mice

Diabetes Pathogenesis - Glucose-mediated pancreatic beta-cell survival is influenced by ERK1/2 control of CREB

Diabetes Pathogenesis - High leptin levels predict type 2 diabetes risk

Diabetes Pathogenesis - Impaired fasting glucose and glucose intolerance are induced by 50% pancreatectomy

Diabetes Pathogenesis - Impaired NH₂ -terminal processing of proislet amyloid polypeptide leads to beta cell death

Diabetes Pathogenesis - In diabetes, endothelial dysfunction of cerebral arterioles requires NO synthase expression

Diabetes Pathogenesis - Insulin regulation of muscle PDK4 mRNA expression impaired in acute insulin-resistant states

Diabetes Pathogenesis - Kisspeptin plays a role in pancreatic islet function

Diabetes Pathogenesis - Paradoxical stimulation of glucagon secretion by high glucose levels assessed in diabetics

Diabetes Prevention - Antidiabetic mechanisms are instigated by supranutritional selenate

Diabetes Prevention - Type 2 diabetes may be prevented using combined metformin plus rosiglitazone

Diabetes Research - Laser procedure is stemming the tide of lower limb amputations among diabetics

Diabetes Research - New diabetes guidelines target foot complications and amputations

Diabetes Research - Transplant treatment approach common to Type 1 Diabetes proves effective for Type 2 Diabetes

Diabetes Therapy - Berberine activates AMPK with beneficial metabolic effects in diabetic and insulin-resistant

Diabetes Therapy - Hyperglycemic impairment is counteracted by benfotiamine

Diabetes Therapy - Intrahepatic transplanted islets secrete insulin in coordinate pulsatile manner to the liver

Diabetes Therapy - Metformin and thiazolidinedione improved glucose control similarly in type 2 diabetics

Diabetes Therapy - Preprandial inhaled insulin delivered by metered-dose inhaler provided adequate metabolic control

Diabetes Therapy - The antidiabetic drug FPFS-410 is limited in bioavailability by bile acids

Diabetes Therapy - Type 1 diabetes glucose metabolism affected by recombinant protein

Diabetic Nephropathy - Combined AGE and ACE inhibition lower diabetic nephropathy progression in B6 db/db mice

Diabetic Nephropathy - Diabetic nephropathy may develop as a result of decreased tetrahydrobiopterin

Diabetic Nephropathy - Glomerular charge, not size, selectivity impaired in diabetic mice with proteinuria

Diabetic Nephropathy - Spironolactone has beneficial impact on nephrotic range albuminuria in diabetic nephropathy

Diabetic Neuropathy - In diabetic neuropathy, no therapeutic difference was seen between oxcarbazepine and placebo

Diabetic Neuropathy - Study validates NC-stat system for detection of diabetic polyneuropathy

Diabetic Retinopathy - Diabetic retinopathy and response to glycemic control are reflected in new rodent models

Diabetic Retinopathy - Diabetic retinopathy models show no response to endothelin-1 blockade

Diet & Nutrition - Brown seaweed contains a promising fat fighter and weight reducer

Diet & Nutrition - Lower body satisfaction predicts behaviors that may place youth at risk for weight gain

Diet & Nutrition - Metabolic responses differ after cod-, milk-, or soy protein meals

Drug Development - Animal research results show nutmeg extracts illicit anti-diabetic activity in rats

Dyslipidemia - Contemporary dyslipidemia management in high-risk patients is suboptimal

Enzymology - Diabetes, obesity or neoplasia therapy may be derived from benzofuran inhibitors of MKP-1

Fitness & Wellness - In youth, physical activity is inversely related to HOMA and IL-6 independent of adiposity

Fitness & Wellness - Inadequate heart rate response to exercise promotes a decline of exercise capacity

Fitness & Wellness - Specialists suggest dancing your way to a better body

Genetics & Genomics - New-onset diabetes after transplant is associated with interleukin-6 promoter polymorphism-174

Heart Disease - Microalbuminuria predicts more severe angiographic coronary artery disease

Hypertension - Amlodipine lowers blood pressure, reduces risk of diabetes in hypertensive patients

Insulin Resistance - Insulin resistance develops after increased p85a expression and IRS-1 serine phosphorylation

Insulin Resistance - Pioglitazone restores HSP72 and tolerance against ischemia/reperfusion injury in rat model

Insulin Resistance - Reduced muscle mitochondrial mass/function contribute to catch-up fat after caloric restriction

Lipid Metabolism - Conjugated docosahexaenoic acid inhibits lipid accumulation in rats

Lipoproteins - Lipoprotein lipid hydroperoxide sequestering peptides release HLDL-related antioxidant enzymes

Market Analysis - Solucient report says hospitals should appeal to women to stem obesity epidemic

Medicaid - McKesson, Colorado healthcare policy office extend Medicaid beneficiaries' diabetes program

Medical Devices - FreeStyle Flash and One Touch Ultra are precise glucose meters

Mergers & Acquisitions - Crdentia announces intent to acquire iVOW, Inc.

Metabolic Syndrome - Oral and transdermal hormone replacement therapies vary in effect on metabolic syndrome factors

Myocardial Infarction - Incomplete ST-segment resolution after reperfusion for acute MI is predicted by hyperglycemia

Obesity & Cardiovascular Disease - Childhood obesity may predict higher cardiovascular disease burden and type 2 diabetes risk

Obesity Complications - BMI and obesity do not predict functional outcome in the dysvascular amputee

Obesity Complications - Both obstructive sleep apnea and obesity can lead to high urinary excretion of 8-isoprostane

Obesity Complications - Obesity may affect induction of oral tolerance following antigen feeding

Obesity Epidemiology - Leptin receptor gene variant contributes to obesity to some degree in KK/Ta mice

Obesity Epidemiology - Obesity appears to be linked to marital status, education level and unemployment

Obesity Management - Portion distortion may contribute to expanding waistlines

Obesity Pathogenesis - Alanine amino transferase levels linked to folate intakes in obese girls

Obesity Pathogenesis - Preadipocyte adipokine secretion profiles are related to fasting plasma glucose

Obesity Therapy - Big benefits reported for obese teenagers who lose weight early with Xenical

Obesity Therapy - Low-dose orlistat provides significant weight loss and improves cholesterol levels, data suggest

Ophthalmology - Obese people twice as likely to go blind