Diabetes & Obesity
Atherosclerosis related gene identified in LDL receptor-deficient C57BL/6 mice
Published in Obesity and Diabetes Week, October 2nd, 2006
"Previous characterization of mouse chromosome 2 identified genomic intervals that influence obesity, insulin resistance, and dyslipidemia. For this, resistant CAST/Ei (CAST) alleles were introgressed onto a susceptible C57BL/6J background to generate congenic strains with CAST alleles encompassing 67-162 Mb (multigenic obesity 6 [MOB6]) and 84-180 Mb (MOB5) from mouse chromosome 2," researchers in the United States report.
D. Estrada-Smith and colleagues at the University of California explained, "To examine the effects of each congenic locus on atherosclerosis and...
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