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Diabetes Complications

Delayed diabetic foot ulcer healing is seen with low foot skin innervation and neurogenic factors

Published in Obesity and Diabetes Week, October 2nd, 2006

In diabetic foot ulcers, a reduction of foot skin innervation and neurogenic factors expression can be correlated with low inflammatory cell accumulation.

"We hypothesize that the reduced innervation of skin can be observed both in clinically neuropathic and non-neuropathic diabetic foot ulcers and can contribute to low inflammatory cell infiltration. Twenty patients with type 2 diabetes and active foot ulcers, without clinical evidence of peripheral sensory neuropathy (n=12) and with sensory neuropathy (n=8) were involved in this study. Biopsies from ulcer margin were examined immunohistochemically," investigators in Poland report.

H. Galkowska and...

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