Diabetes Control

Type 1 diabetes glucose control with insulin reduces blood cell binding activity

Published in Obesity and Diabetes Week, October 2nd, 2006

According to recently published research from the United States, glucose control with insulin results in reduction of NF-kappa B-binding activity in mononuclear blood cells of patients with recently manifested type 1 diabetes.

"Chronic elevated blood glucose levels are associated with the formation of advanced glycation endproducts (AGEs). Hyperglycaemia and AGEs have been shown to induce activation of the redox-sensitive transcription factor nuclear factor-kappa B (NF-kappa B).

"To validate the hypothesis that the maintenance of normal glucose levels results in the reduction of NF-kappa B-binding activity in vivo, the redox-sensitive transcription...

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Source: Obesity and Diabetes Week (2006-10-02)

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