Apoptosis
Pancreatic beta-cell apoptosis involves transcription factor activation
Published in Obesity and Diabetes Week, October 2nd, 2006
"Amylin-mediated islet beta-cell death is implicated in diabetogenesis. We previously reported that fibrillogenic hA evokes beta-cell apoptosis through linked activation of Jun N-terminal kinase 1 (JNK 1) and a caspase cascade.
"Here we show that p38 MAP kinase became activated by hA treatment of cultured beta-cells whereas extracellular signal-regulated kinase (ERK) did not; by contrast, nonfibrillogenic rat amylin (rA)...
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