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Diabetes Complications

alpha-Lipoic acid prevents diabetes-induced atherosclerosis in mouse model

Published in Obesity and Diabetes Week, October 9th, 2006

alpha-Lipoic acid prevents the increase in atherosclerosis induced by diabetes in apolipoprotein e-deficient mice fed high-fat/low-cholesterol diet.

According to recent research from the United States, "Considerable evidence indicates that hyperglycemia increases oxidative stress and contributes to the increased incidence of atherosclerosis and cardiovascular complications in diabetic patients. To examine the effect of a-lipoic acid, a potent natural antioxidant, on atherosclerosis in diabetic mice, 3-month-old apolipoprotein (apo) E-deficient (apoE-/-) mice were made diabetic by administering streptozotocin (STZ)."

X.W. Yi and colleagues...

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