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Diabetes & Obesity

Pro12Ala variant of PPAR-gamma2 gene is linked to high diastolic blood pressure in obese diabetics

Published in Obesity and Diabetes Week, October 23rd, 2006

The Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene is associated with an increased mean 24-h diastolic blood pressure in obese diabetic patients.

According to a study from Poland, "The aim of the study was to examine an association between the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor (PPAR)-gamma 2 gene and blood pressure values assessed by 24-h ambulatory blood pressure monitoring (ABPM) in obese patients with long-lasting type 2 diabetes. Two hundred and fourteen obese patients (95 men and 119 women) with above 10-year history of type 2 diabetes were recruited for the study."

"In all...

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