Neurology
Circulating ghrelin concentrations are lowered by intracerebroventricular insulin
Published in Obesity and Diabetes Week, November 6th, 2006
"Ghrelin is a peptide that is mainly produced by the stomach and stimulates food intake, adiposity and weight gain. Previous studies have documented that plasma levels of ghrelin are reduced by insulin, but the mechanisms that mediate this effect are unclear," investigators in Brazil report.
M. Ueno and colleagues working with Campinas State University described, "To determine whether phosphatidylinositol 3-kinase (PI(3)K) and/or mitogen-activated protein kinase (MAPK) are involved in this insulin action, we tested the intracerebroventricular (i.c.v.) effect of...
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