Obesity Pathogenesis
In the muscle of obese, SOCS3 inhibits leptin activation of AMP-kinase
Published in Obesity and Diabetes Week, November 6th, 2006
"Leptin is thought to regulate whole-body adiposity and insulin sensitivity, at least in part, by stimulating fatty acid metabolism via activation of AMP-kinase (AMPK) in skeletal muscle. Human obesity is associated with leptin resistance, and recent studies have demonstrated that hypothalamic expression of the suppressors of cytokine signaling 3 (SOCS3) regulates leptin sensitivity in rodents," scientists writing in the Journal of Clinical Endocrinology and Metabolism report.
G.R. Steinberg and colleagues at the...
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