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Diabetes Complications

Squamous cell carcinoma of forestomach is induced in diabetic rats by single alloxan treatment

Published in Obesity and Diabetes Week, November 6th, 2006

Induction of squamous cell carcinoma of forestomach in diabetic rats is achieved by single alloxan treatment.

"Male rats of WBN/Kob strain are one of the diabetic model animals and develop long-lasting diabetic symptoms and some complications from about 40 weeks of age without any treatment. A single intravenous dose of alloxan, a nongenotoxic diabetogenic chemical, frequently induced proliferative lesions of squamous epithelium in tongue, esophagus and forestomach of male and female WBN/Kob rats, and hastened the onset and acceleration of diabetic conditions," investigators in Japan report.

Y. Kodama and colleagues working with Setsunan University...

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