Endocrinology
Hyper-responsiveness to neuropeptide Y may account for hyperphagia seen in PVN-lesioned rats
Published in Obesity and Diabetes Week, November 6th, 2006
"Bilateral electrolytic lesions of the paraventricular nucleus of the hypothalamus (PVN) produce hyperphagia with excess weight gain. The orexigenic neuropeptide Y (NPY) system and the anorexigenic melanocortin system act in the PVN to regulate food intake, and participate in mediating the anorexic effects of leptin," investigators in the United States report.
M.G. Dube and colleagues at the University of Florida hypothesized "changes in the responsiveness of these systems may contribute to the...
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