Diabetes Epidemiology
Transcription factor 7-like 2 (TCF7L2) gene polymorphisms are linked to type 2 diabetes in Amish
Published in Obesity and Diabetes Week, November 13th, 2006
According to recent research from the United States, "Transcription factor 7-like 2 (TCF7L2) regulates genes involved in cell proliferation and differentiation. The TCF7L2 gene is located on chromosome 10q25 in a region of replicated linkage to type 2 diabetes. Recently, a micro-satellite marker in intron 3 (DG10S478) and five correlated single nucleotide polymorphisms (SNPs) were identified in Icelandic individuals that showed strong association with type 2 diabetes, which was replicated in Danish and European-American cohorts."
C.M....
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