DNA Research
mtDNA D-loop variant worsens pancreatic cancer prognosis and may indicate diabetes risk
Published in Obesity and Diabetes Week, November 13th, 2006
According to recent research from Italy, "We ascertained the frequency of mitochondrial DNA (mtDNA) D-loop region somatic mutations in pancreatic cancer (PC) and verified whether polymorphisms were linked to diagnosis, prognosis, and PC-associated diabetes mellitus (DM) in 99 PC cases, 42 chronic pancreatitis (CP) cases, 18 pancreatobiliary tract tumors, and 87 healthy control subjects. Tissue samples were obtained from 19 patients with PC and 5 with CP The D-loop region was sequenced from all tissue samples and from blood...
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