Obesity & Diabetes Week
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Obesity and Diabetes
Studies from Beth Israel Deaconess Medical Center yield new information about obesity and diabetes
December 11th, 2006
Researchers detail in "TLR4 links innate immunity and fatty acid-induced insulin resistance," new data in obesity and diabetes. According to a study from the United States, "TLR4 is the receptor for LPS and plays a critical role in innate immunity. Stimulation of TLR4 activates proinflammatory pathways and induces cytokine expression in a variety of cell types." "Inflammatory pathways are activated in tissues of obese animals and humans and play an important role in obesity-associated insulin resistance. Here we show that nutritional fatty acids, whose circulating levels are often increased in obesity, activate TLR4 signaling in adipocytes and macrophages and that the...
Source: Obesity & Diabetes Week (2006-12-11)
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