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Type 1 Diabetes

Immune responses spread from one protein to another in type 1 diabetes

Published in Obesity and Diabetes Week, December 18th, 2006

In a study appearing in the Journal of Clinical Investigation, researchers from St. Vincent's Institute, Australia, have shown that in a mouse model of Type 1 diabetes, the immune system first attacks a single protein, known as proinsulin, and then expands its attack to other proteins.

Type 1 diabetes (T1D) is caused by the immune system inappropriately attacking the cells in the pancreas that produce insulin, the hormone that controls blood sugar levels. Although many of the proteins attacked by the immune system during T1D have been identified, it has not been determined whether immune responses to the individual proteins develop independently or whether a...

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