Diabetes Research

Immune responses spread from one protein to another in type 1 diabetes

Published in Obesity and Diabetes Week, December 25th, 2006

Type 1 diabetes (T1D) is caused by the immune system inappropriately attacking the cells in the pancreas that produce insulin, the hormone that controls blood sugar levels. Researchers from St. Vincent's Institute, Australia, have shown that in a mouse model of T1D the immune system first attacks a single protein, known as proinsulin, and then expands its attack to other proteins.

Their study appeared in a recent issue of the Journal of Clinical Investigation.

Using mice that develop a disease very similar to T1D (NOD mice), Thomas Kay and colleagues showed that NOD mice that were unable to mount an immune response to proinsulin also had no...

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Source: Obesity and Diabetes Week (2006-12-25)

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