Obesity Research
Enzyme may offer key to antiobesity therapy
Published in Obesity and Diabetes Week, February 26th, 2007
Researchers have discovered a pivotal new player in early events that commit fat cell precursors to becoming full-blown fat, according to a report in the journal Cell Metabolism, published by Cell Press. Drugs that block some activities of the enzyme, known as xanthine oxidoreductase (XOR), might therefore offer a novel antiobesity therapy designed to fight fat before it even forms, the researchers said.
Known for its role in producing the metabolic byproduct uric acid, XOR had earlier been implicated in gout, said Jeffrey Friedman of The Rockefeller University, senior author of the study. Gout is a painful type of arthritis that results when uric acid crystals...
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