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Obesity and Diabetes

Reports outline obesity and diabetes study results from Monash University

Published in Obesity and Diabetes Week, February 26th, 2007

New research, "Beta cells cannot directly prime diabetogenic CD8 T cells in nonobese diabetic mice," is the subject of a report. "Type 1 diabetes (T1D) is caused by the destruction of insulin-producing islet beta cells. CD8 T cells are prevalent in the islets of T1D patients and are the major effectors of beta cell destruction in nonobese diabetic (NOD) mice," investigators in Melbourne, Australia report.

"In addition to their critical involvement in the late stages of diabetes, CD8 T cells are implicated in the initiation of disease. NOD mice, in which the beta2-microglobulin gene has been inactivated by gene targeting (NOD.beta2M-/-), have a deficiency in CD8 T cells...

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