Obesity and Diabetes
Research on obesity and diabetes published by scientists at State University of Maringa
Published in Obesity and Diabetes Week, February 26th, 2007
Data detailed in "Muscarinic M2 receptor is active on pancreatic islets from hypothalamic obese rat" have been presented. According to a study from Maringa, Brazil, "Hypothalamic obese rats, obtained by neonatal treatment with monosodium L-glutamate (MSG), are hyperinsulinemic, and secrete more insulin than lean ones do when stimulated by glucose, while acetylcholine insulinotropic effect decreases. The effect of acetylcholine on glucose-induced insulin secretion is attributed to muscarinic receptors of pancreatic beta cells, mainly to M(3) subtype."
"However, it has been observed that activation of M(2) or M(4) subtypes causes inhibition of glucose-induced insulin...
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