Obesity Genetics
Studies from Inha University, Institute for Medical Science have provided new data on obesity genetics
Published in Obesity and Diabetes Week, March 5th, 2007
New research, "Excessive nitric oxide attenuates leptin-mediated signal transducer and activator of transcription 3 activation," is the subject of a report. "The mechanisms of leptin resistance observed in most cases of human obesity are poorly understood. Therefore, we evaluated the effects of nitric oxide (NO) on the leptin-induced activation of Janus kinase/signal transducer and activator of transcription 3 (JAK/STAT3) pathways and on the leptin receptor (LEPR) expression using SH-SY5Y cells," scientists in South Korea report.
"Here, we show that the NO donor spermine/NONOate inhibited leptin-induced activation of STAT3 in vitro. The inhibition of leptin-mediated...
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