Obesity and Diabetes
New research on obesity and diabetes from Geneva University summarized
Published in Obesity and Diabetes Week, June 4th, 2007
Scientists discuss in "Inhibition of insulin secretion by betagranin, an N-terminal chromogranin A fragment" new findings in obesity and diabetes. According to recent research published in the Journal of Biological Chemistry, "Betagranin, an N-terminal fragment of chromogranin A, results from a proteolytic processing, and is co-secreted with insulin. While other chromogranin A-derived peptides negatively modulate hormone secretion, the role of betagranin in pancreatic beta-cells is so far unknown."
"We have recently shown that pancreatic islet betagranin levels are down-regulated in obese, leptin-deficient mice. In the present study, we have investigated the...
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