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Obesity

Research results from University Hospital update knowledge of obesity

Published in Obesity and Diabetes Week, June 4th, 2007

Fresh data on obesity are presented in the report "Adipocyte-derived products induce the transcription of the StAR promoter and stimulate aldosterone and cortisol secretion from adrenocortical cells through the Wnt-signaling pathway." According to a study from Dusseldorf, Germany, "Obesity is associated with hypersecretion of cortisol and aldosterone and a high prevalence of arterial hypertension. At the cellular level, a direct effect of adipocytes on the expression of the steroidogenic acute regulatory (StAR) protein, a regulator of cortisol and aldosterone synthesis, and on aldosterone and cortisol secretion has been shown."

"However, the molecular mechanisms...

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