Obesity and Diabetes

Hormone Ignites the Body's Fat-Burning Furnace

Published in Obesity and Diabetes Week, June 25th, 2007

Researchers have identified a master hormone that allows the body to fuel itself with stored fat during times of fasting. The hormone mobilizes lipids from fat cells, and then directs the liver to transform those lipids into energy-rich molecules that circulate throughout the body.

The researchers said their findings reveal a more complete picture of the far-reaching role of the hormone, fibroblast growth factor 21 (FGF21), which is already in development as a treatment for type 2 diabetes. In addition to switching the body to a fat-burning mode, the team found FGF21 induces the hibernation-like state of torpor that conserves energy in fasting animals.

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Source: Obesity and Diabetes Week (2007-06-25)

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