Obesity
Researchers' work from University of Tokyo, Institute of Molecular and Cellular Biosciences focuses on obesity
Published in Obesity and Diabetes Week, July 30th, 2007
Researchers detail in "The pituitary function of androgen receptor constitutes a glucocorticoid production circuit," new data in obesity. According to recent research from Tokyo, Japan, "Androgen receptor (AR) mediates diverse androgen actions, particularly reproductive processes in males and females. AR-mediated androgen signaling is considered to also control metabolic processes; however, the molecular basis remains elusive."
"In the present study, we explored the molecular mechanism of late-onset obesity in male AR null mutant (ARKO) mice. We determined that the obesity was caused by a hypercorticoid state. The negative feedback system regulating glucocorticoid...
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