Published in Obesity and Diabetes Week, September 17th, 2007
"Studies with SCD1 knockout mice have established that these animals are lean and protected from leptin deficiency-induced and diet-induced obesity, with greater whole body insulin sensitivity than wild-type animals. In this work, we have discovered a series of potent, selective, orally bioavailable SCD1 inhibitors based on a known pyridazine carboxamide template," wrote G. Liu and colleagues.
The researchers concluded: "The representative lead inhibitor...
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