Obesity and Diabetes

Research by R.D. Kineman and colleagues in obesity and diabetes provides new insights

Published in Obesity and Diabetes Week, October 8th, 2007

According to a study from the United States, "The mouse ghrelin gene contains 5 exons (Ex), with Ex2-Ex5 encoding a 117 amino acid preproprotein that is processed to yield a 28 amino acid mature peptide. The current study examined if pituitary (PIT) and hypothalamus (HPT) ghrelin expression is up-regulated in response to fasting and down-regulated in obesity, as previously reported in the stomach."

"In the process of establishing a quantitative real-time RT-PCR system to accurately assess the changes in PIT and HPT ghrelin mRNA levels, we observed that primer sets located in Ex2 and Ex3 amplified a ghrelin transcript that contained the entire intron 2 (In2). Size and...

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Source: Obesity and Diabetes Week (2007-10-08)

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