Obesity

Research from Harvard University has provided new information about obesity

Published in Obesity and Diabetes Week, October 22nd, 2007

According to a study from the United States, "'Brown fat cells are specialized to dissipate energy and can counteract obesity; however, the transcriptional basis of their determination is largely unknown. We show here that the zinc-finger protein PRDM16 is highly enriched in brown fat cells compared to white fat cells."

"When expressed in white fat cell progenitors, PRDM16 activates a robust brown fat phenotype including induction of PGC-1 alpha, UCP1, and type 2 deiodinase (Dio2) expression and a remarkable increase in uncoupled respiration. Transgenic expression of PRDM16 at physiological levels in white fat depots stimulates the formation of brown fat cells....

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Source: Obesity and Diabetes Week (2007-10-22)

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