Published in Obesity and Diabetes Week, October 22nd, 2007
"When expressed in white fat cell progenitors, PRDM16 activates a robust brown fat phenotype including induction of PGC-1 alpha, UCP1, and type 2 deiodinase (Dio2) expression and a remarkable increase in uncoupled respiration. Transgenic expression of PRDM16 at physiological levels in white fat depots stimulates the formation of brown fat cells....
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