Obesity and Diabetes

Data from J. Zhang et al provide new insights into obesity and diabetes

Published in Obesity and Diabetes Week, October 29th, 2007

According to a study from Nishinomiya, Japan, "'Aims/hypothesis We examined the effect of glucagon-like peptide-1 (GLP-1) on the development of diabetes and islet morphology in NOD mice by administering GLP-1 to prediabetic mice. Eight-week-old female NOD mice were infused subcutaneously with human GLP-1 via a mini-osmotic pump for 4 or 8 weeks."

"In mice treated with GLP-1 for 4 weeks, blood glucose levels and body weight were measured. An intraperitoneal glucose tolerance test (IPGTT) and evaluation of insulitis score were also performed. Beta cell area, proliferation, apoptosis, neogenesis from ducts and subcellular localisation of forkhead box O1 (FOXO1) were...

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Source: Obesity and Diabetes Week (2007-10-29)

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