Obesity and Diabetes Prevention
Study results from P.M. Seraphim and colleagues broaden understanding of obesity and diabetes prevention
Published in Obesity and Diabetes Week, November 19th, 2007
Current study results from the report, 'Age related obesity-induced shortening of GLUT4 mRNA poly(A) tail length in rat gastrocnemius skeletal muscle,' have been published. "Obese insulin resistant animals and humans have shown reduced GLUT4 gene expression. Yet, in skeletal muscle, discrepancy between mRNA and protein regulation has been frequently observed, suggesting a post-transcriptional modulation," scientists writing in the journal Molecular and Cellular Endocrinology report.
"We investigated the GLUT4 expression in adipose tissue and muscle of obese 12-month-old (12-mo) rats, comparing with lean 2-month-old (2-mo) animals. Obesity was accompanied by...
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