Obesity and Diabetes

Scientists at University of Florida release new data on obesity and diabetes

Published in Obesity and Diabetes Week, November 26th, 2007

"Leptin, a product of the ob gene, is a pleiotropic signal implicated in regulation of multiple physiological functions in the periphery and centrally, including hypothalamic integration of energy homeostasis. Recessive mutations of ob gene result in early onset of hyperphagia, morbid obesity, metabolic disorders, early mortality and shortened life-span," scientists in the United States report.

"Intracerebroventricular injection of recombinant adeno-associated virus vector (rAAV) encoding the leptin gene in adult obese oblob mice enhanced leptin transgene expression only in the hypothalamus, normalized food intake, body weight and more than doubled the life-span as...

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Source: Obesity and Diabetes Week (2007-11-26)

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