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Sepsis

Data from University of Queensland advance knowledge in sepsis

Published in Obesity and Diabetes Week, December 3rd, 2007

According to recent research from Brisbane, Australia, "Changes in cortisol metabolism due to altered activity of the enzyme 11 beta-hydroxysteroid dehydrogenase (11 beta- HSD) have been implicated in the pathogenesis of hypertension, obesity and the metabolic syndrome. No published data exist on the activity of this enzyme in critical illness To investigate cortisol metabolism in critically ill patients utilising plasma cortisol: cortisone ratio as an index of 11 beta-HSD activity Tertiary level intensive care unit Three cohorts of critically ill patients: sepsis ( n = 13); multitrauma (n = 20); and burns (n = 19) Serial plasma cortisol: cortisone ratios."

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