Diabetes Prevention
New findings reported from Institute of Basic Medical Science, Department of Molecular Immunology describe advances in diabetes prevention
Published in Obesity and Diabetes Week, December 3rd, 2007
Current study results from the report, 'Mechanisms of regulatory T-cell induction by antigen-IgG-transduced splenocytes,' have been published. "Our previous studies have demonstrated that splenocytes, transduced with glutamate decarboxylate 65 (GAD) and IgG fusion construct, protect non-obese diabetes (NOD) mice from diabetes. However, the mechanism by which this strategy prevents diabetes is not well understood," researchers in Beijing, People's Republic of China report.
"Here, we found that CD4(+)Foxp3(+)Treg cells, in vitro induced by GAD-IgG-transduced splenocytes, after transfer, were responsible for prevention of diabetes in NOD mice. Further studies suggested...
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