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Prostate Cancer

Obesity-linked high blood volumes render PSA prostate cancer test less effective, study suggests

Published in Obesity and Diabetes Week, December 3rd, 2007

The extra blood volume produced in the obese may so dilute levels of a telltale protein produced by prostates that the popular PSA test may be essentially useless for diagnosing prostate cancer in men carrying extra pounds, a new study in The Journal of the American Medical Association suggests.

The new research, combining data from more than 13,000 prostate cancer patients at The Johns Hopkins Hospital and elsewhere, could eventually affect the reliability of scores of other blood tests for cancer and other diseases in obese people, or at least alter the way those tests are analyzed, investigators say.

The predictive value of the PSA test depends on...

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