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Obesity and Diabetes Cell Biology
New obesity and diabetes cell biology study results reported from Institute of Molecular Biotechnology
December 10th, 2007
Investigators publish new data in the report 'Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes.' "Type-2 diabetes results from the development of insulin resistance and a concomitant impairment of insulin secretion. Recent studies place altered mitochondrial oxidative phosphorylation (OxPhos) as an underlying genetic element of insulin resistance," scientists writing in the journal Cell report. "However, the causative or compensatory nature of these OxPhos changes has yet to be proven. Here, we show that muscle-and liver-specific AIF ablation in mice initiates a pattern of OxPhos deficiency closely...
Source: Obesity & Diabetes Week (2007-12-10)
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