Published in Obesity and Diabetes Week, January 14th, 2008
"However, its pathogenic role in SSc remains unclear. We investigated whether induction of an autoreactive antibody response is directly pathogenic in mice. Autoimmune responses were induced in mice immunized with human recombinant topo-I (rhutopo-I). Both Immoral and T cell-mediated autoimmune responses were assessed. Necropsy analyses were performed to determine pathologic changes in immunized mice. Autoimmune prone SJL and non-obese diabetic...
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