Diabetes

Research on diabetes discussed by K. Macaulay and co-researchers

Published in Obesity and Diabetes Week, January 14th, 2008

"Glycogen synthase kinase 3 comprises two isoforms (GSK-3 alpha and GSK-3 beta) that are implicated in type II diabetes, neurodegeneration,and cancer. GSK-3 activity is elevated in human and rodent models of diabetes, and various GSK-3 inhibitors improve glucose tolerance and insulin sensitivity in rodent models of obesity and diabetes," scientists in Toronto, Canada report.

"Here, we report the generation of mice lacking GSK-3 alpha. Unlike GSK-3 beta mutants, which die before birth, GSK-3 beta knockout (GSK-3 alpha KO) animals are viable but display enhanced glucose and insulin sensitivity accompanied by reduced fat mass. Fasted and glucose-stimulated hepatic glycogen...

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Source: Obesity and Diabetes Week (2008-01-14)

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