Obesity Animal Studies
Research from N. Vrang and co-researchers yields new findings on obesity animal studies
Published in Obesity and Diabetes Week, February 25th, 2008
Researchers detail in 'Upregulation of the brainstem preproglucagon system in the obese Zucker rat,' new data in obesity. "A group of neurons in the caudal nucleus of the solitary tract (NTS) processes preproglucagon to glucagon-like peptide 1 (GLP-1), GLP-2 and oxyntomodulin. Whereas the anorectic capacity of all three neuropeptides has been demonstrated, only relatively little is known of preproglucagon mRNA regulation in the brain stem," scientists in Denmark report.
"Using in situ hybridization and fluorescence immunohistochemistry, we examined hindbrain preproglucagon expression in lean and obese Zucker rats under different metabolic perturbations. First, the...
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