Drug Development
Research from Sanofi Aventis in drug development provides new insights
Published in Obesity and Diabetes Week, March 17th, 2008
Scientists discuss in 'Inhibition of lipolysis by palmitate, H2O2 and the sulfonylurea drug, glimepiride, in rat adipocytes depends on cAMP degradation by lipid droplets' new findings in drug development. According to recent research published in the journal Biochemistry, "The release of fatty acids and glycerol from lipid droplets (LD) of mammalian adipose cells is tightly regulated by a number of counterregulatory signals and negative feedback mechanisms. In humans unrestrained lipolysis contributes to the pathogenesis of obesity and type II diabetes."
"In order to identify novel targets for the pharmacological interference with lipolysis, the molecular...
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