Obesity and Diabetes Genetics
Studies from University of Tokushima reveal new findings on obesity and diabetes genetics
Published in Obesity and Diabetes Week, March 31st, 2008
New investigation results, 'Diabetic modifier QTLs in F(2) intercrosses carrying homozygous transgene of TGF-beta,' are detailed in a study published in Mammalian Genome. According to recent research from Tokushima, Japan, "When the homozygous active form of porcine TGF-beta1 transgene (Tgf/Tgf) (under control of the rat glucagon promoter) is introduced into the nonobese diabetic mouse (NOD) genetic background, the mice develop endocrine and exocrine pancreatic hypoplasia, low serum insulin concentrations, and impaired glucose tolerance. To identify genetic modifiers of the diabetic phenotypes, we crossed hemizygous NOD-Tgf with DBA/2J mice (D2) or C3H/HeJ mice (C3H) and used the...
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