Published in Obesity and Diabetes Week, April 28th, 2008
"In the present study, we investigated the expression pattern of URB mRNA in adipose tissue and secretion from cultured adipocytes. In human and mouse, URB mRNA was predominantly expressed in adipose tissue and was downregulated in obese mouse models, such as ob/ob, KKAy, and diet-induced obese mice. In 3T3L1 adipocytes, insulin, TNF-alpha, H2O2 and hypoxia decreased URB mRNA level. This regulation was similar to that for...
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