Chirality

Study findings from P.C. Nair et al broaden understanding of chirality

Published in Obesity and Diabetes Week, June 16th, 2008

According to recent research from India, "Chemokines are small molecular weight water-soluble proteins playing a key role in immunomodulation and host-defense mechanisms. CCR2 receptor is targeted for diseases like arthritis, multiple sclerosis, vascular disease, obesity, and type 2 diabetes."

"Reported, herein are the QSAR studies performed on a diverse set of enantiopure analogues reported as CCR2 antagonists by hologram analysis. The best model highlights the importance of chirality feature in comparison with the other models developed without the chirality. The validated model showed high internal and external predictive power. The robustness of the model was...

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Source: Obesity and Diabetes Week (2008-06-16)

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