Obesity

Study results from Johns Hopkins University provide new insights into obesity

Published in Obesity and Diabetes Week, June 23rd, 2008

According to a study from the United States, "Disruption of leptin signaling has been associated with both obesity and heart failure. We recently demonstrated that leptin deficiency in ob/ob mice and leptin insensitivity in db/db mice leads to increased myocyte apoptosis and left ventricular (LV) hypertrophy."

"We showed that LV mass, while similar among young ob/ob, and wild type (WT) mice, is significantly higher in old ob/ob and db/db versus WT. Ob/ob and db/db mice developed markedly increased rates of myocyte apoptosis by TUNEL and activated caspase-3 levels. An intriguing candidate for the study of obesity-associated cardiac hypertrophy and apoptosis is PI3K,...

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Source: Obesity and Diabetes Week (2008-06-23)

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