Obesity and Diabetes

Scientists at Malmo University describe research in obesity and diabetes

Published in Obesity and Diabetes Week, July 28th, 2008

According to recent research from Malmo, Sweden, "Variants in the TCF7L2 gene (transcription factor 7-like 2) have shown strong association with type 2 diabetes with two defined risk haplotypes, HapA and HapB(T2D)). TCF7L2 may play a role in both glucose homeostasis and adipogenesis."

"Our aim was to characterize the TCF7L2 mRNA expression and regulation in human adipose tissue. We quantified TCF7L2 mRNA levels in cultured human adipocytes and in biopsies from visceral (VAT) and subcutaneous (SAT) adipose tissue from 38 obese non-diabetic subjects, using real-time PCR. The influence of haplotype and clinical traits on TCF7L2 mRNA levels were investigated. In vitro,...

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Source: Obesity and Diabetes Week (2008-07-28)

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