Obesity and Diabetes

Scientists at Marshall University publish new data on developmental biology

Published in Obesity and Diabetes Week, August 4th, 2008

According to a study from the United States, "The Drosophila wing is a primary model system for studying the genetic control of epithelial Planar Cell Polarity (PCP). Each wing epithelial cell produces a distally pointing hair under the control of the Frizzled (Fz) PCP signaling pathway."

"Here, we show that Fz PCP signaling also controls the formation and orientation of ridges on the adult wing membrane. Ridge formation requires hexagonal cell packing, consistent with published data showing that Fz PCP signaling promotes hexagonal packing in developing wing epithelia. In contrast to hair polarity, ridge orientation differs across the wing and is primarily...

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Source: Obesity and Diabetes Week (2008-08-04)

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